EMBO Practical Course: Metabolomics Bioinformatics in Human Health Programme and Faculty


This EMBO Practical Course will not only provide face-to-face training, but also offers a unique opportunity for students to speak with experts for the duration of the course. This high-level engagement contributes to the development of a network of scientists working at all levels of the field. Integrating metabolomic data with other “omics” data is increasingly common, but requires a background understanding of the topic to generate high-quality results. Our course now looks to provide instruction for interpretation of complex omics data, allowing researchers to combine multiple dimensions of metabolism in their analyses.

During this course, you will learn about:
– Metabolomics study design, workflows and sources of experimental error, the difference between target and un-target approaches
– Metabolomics data processing tools: hands-on open source R based programs, XCMS, MetFrag, MetFusion, rNMR, BATMAN
– Metabolomics data analysis: Using R Bioconductor, understanding the usage of univariate and multivariate data analysis, data fusion concepts, data clustering and regression methods
– Metabolomics downstream analyses: KEGG, BioCyc, and MetExplore for metabolic pathway and network analysis with visualisation of differential expression, understanding metabolomics flux analysis
– Metabolomics standards and databases: data dissemination and deposition in EMBL- EBI MetaboLights repository; PHENOMenal, workflows4metabolomics
– Metabolomics Flux and Stable Isotope Resolved Metabolomics (SIRM)

After this course you should be able to:
– Discuss the major principles of metabolomics experimental design and factors that impact upon subsequent analysis
– Identify strengths and weaknesses in a variety of metabolomics analytical approaches
– Use a range of Bioinformatics software to pre-process, process and analyse metabolomics data
– Discuss current trends and challenges in metabolomics

Detailed programme: Not available

List of faculty: Not available